478 MICAL2, upregulated by β-catenin, induces invasion in melanoma

The Wnt/β-catenin signaling pathway plays a key role during embryonic development, homeostasis and cancer. of β-catenin in melanocyte lineage establishment has been elucidated, but its melanoma remains poorly defined. In particular, function cell invasion is controversial. Especially, we generated signature activation to emerge proteins interest including known target genes (AXIN2, APCDD1, NKD1, SP5, NOTUM, ZNRF3, CCND1 PPARD) new (SLC1A5, SLC7A11, SLC24A4 MICAL2). Our gene most correlated with invasive cells MICAL2. MICAL2 oxidizes actin filaments, destabilizes them, modifies the migratory power cells. lines, reduction or induction reduces increases level MICAL2, respectively. Decreasing migration, growth. Finally, significantly unfavorable evolution for patient associated strong expression power. conclusion, identification transcriptional an important step towards understanding melanomagenesis. which pharmacologically targetable example.